(Senior) Scientist, Proteomics

Company Summary:

Ampersand Biomedicines is an innovative, privately held biotechnology company leading the way in developing multi-specific medicines that direct a wide range of therapeutic molecules to specific cells and biological contexts (www.Ampersand.bio).  Ampersand was founded in Flagship Pioneering’s venture creation engine, where companies such as Moderna Therapeutics (NASDAQ: MRNA) and Seres Therapeutics (NASDAQ: MCRB) were conceived and created.  With a strong emphasis on innovation, Ampersand cultivates a highly dynamic and entrepreneurial environment. 

Position Summary:

Ampersand is currently seeking a highly motivated team member in cell membrane proteomics to further extend our platform that targets drug activity to specific cells and/or tissues. Working in a cross-functional environment, the position will involve developing and implementing technologies for the identification and validation of tissue and cell-specific drug targets.  The final job title for this position will be determined based on the candidate's level of experience. 

You will be expected to design and execute experiments to assess cell and tissue specific expression patterns of candidate antigens and to validate tissue and cell specific binding of in-house developed biologics. This role offers the opportunity to work in a dynamic, fast-paced, entrepreneurial environment, where you will have the chance to work independently and collaboratively within a highly integrated team. This is an on-site role in South Boston.

Key Responsibilities:

• Design, plan, and execute proteomic studies to support target selection of multi-specific antibodies.
• Develop tissue assays to assess binding and drug activity patterns of therapeutic antibodies and multi-specific molecules across portfolio projects, particularly in the fields of inflammation and immunology.
• Collaborate with our Protein Sciences team to optimize the developability profiles of candidate molecules, and with the In Vivo Pharmacology team to evaluate tissue specific PK/PD, efficacy, and toxicity.
• Collaborate with and oversee research activities conducted by Contract Research Organizations (CROs) and partners.
• Contribute to preparing and writing INDs for therapeutic candidates.
• Maintain scientific and technical expertise through familiarity with scientific literature.
• Contribute to building a positive, team-oriented biotech culture.

Qualifications:

• PhD or equivalent experience in proteomics with 3 years additional experience, preferably in a drug discovery setting.
• Demonstrated experience in the following areas:
• Developing and implementing studies to compare protein expression on cell surfaces and in different tissue types.
• Designing, performing and analyzing mass spectrometry experiments.
• Characterizing epitope accessibility on cell surfaces.
• Cell culture and protein enrichment techniques.
• Analysis, cataloguing, and mining multiomic data in collaboration with data scientists.
• Excellent written and verbal communication skills and experience presenting results and scientific data to team leaders, cross-functional teams, academic collaborators, or partners.
• Enthusiasm for playing a pivotal role in the dynamic and multidisciplinary environment of a small biotech.

About Flagship

Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.

Flagship Pioneering is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.